Metabolic Perturbations With Autism Induced By Plasticizers
The focus of the project is to understand how Bisphenol A can affect metabolism in some mothers and children with Autism Spectrum Disorders (ASD).
Bisphenol A (BPA) is a component of many plastics. BPA is generally recognized
as safe and is widely used. We recently completed a study on Autistic children
and BPA where differences in exposure and metabolic subtleties were found when
compared against a group of control children. The results suggested that BPA
alters some aspects of intermediary metabolism in some children with Autism
spectrum Disorders ASD. The objectives of the proposed study are to explain and
extend these our findings by investigating whether these metabolic differences
are also found in the mothers of children with ASD. Such a finding would
suggest a genetic linkage in how BPA is metabolized between mothers and some
children with ASD.