Bridging behavior and genetics through sensory-motor electrophysiology

This project aims to bridge the gap between behavior and genetics in individuals, and families affected by Autism Spectrum Disorders (ASD). Using objective metrics that encapsulate physiological processes ranging from sensory-motor control, to temperature regulation and electrodermal activity, we will begin to profile and truly understand the underlying characteristics associated with a diagnosis of ASD. This characterization will be further viewed in light of sensory-motor and physiological profiling of individuals with Fragile X disorders (FXDs).

Growing research has demonstrated the presence of predictable sensory-motor variation in individuals with ASD. In particular, our lab has begun to highlight the role of sensory-motor control in a diagnosis of ASD, with characteristics clearly differentiating between individuals with ASD and neuro-typical controls (1-3). The presence of such sensory-motor difficulties provides new avenues of research, from demonstrating how these core issues may give rise to problems such as socialization, to aiding in the development of targeted, personalized therapeutic interventions. One important question is how sensory-motor and physiological control, which can be objectively measured and quantified, may help further our understanding of the underlying etiology of ASD.