Piloting Electrophysiologic Biomarkers for ASD and Related Disorders in Premature and Low Birth Weight InfantsShort Title
This pilot project will investigate the use of very early markers to identify children with Autism among premature and low birth-weight children
Because Autism Spectrum Disorders are behaviorally defined, a formal diagnosis cannot reliably be made until the child is at least 2 years old. However, there is evidence that there are changes occurring in the child's development much earlier. As a result, intervention efforts miss a critical window for earlier diagnosis, prevention and treatment. While the majority of children diagnosed with autism are full term babies, the risk for preterm /low birth weight (LBW) babies is considerably higher. We will therefore carefully study children born preterm/LBW to see which children develop early signs of ASD. We will be using promising very early markers that we hope to develop into a screening tool to detect which children are at risk of developing ASD. These early markers include: exposure to prenatal inflammation, measures of changes to the developing immune system, and poor visual tracking and atypical early motor behavior. Our ultimate goal is to examine the relationship among these markers in order to predict which children are at risk for development of ASD. This will lead to earlier interventions and improved outcomes.